We extend some two Higgs doublet models, where the blackmores ache relief focus review Yukawa couplings for the charged fermion mass generation only involve one Higgs doublet, by two singlet scalars respectively carrying a singly electric charge and a doubly electric charge.The doublet and singlet scalars together can mediate a two-loop diagram to generate a tiny Majorana mass matrix of the standard model neutrinos.Remarkably, the structure of the neutrino mass matrix is fully determined by the symmetric Yukawa couplings craggy range sauvignon blanc 2022 of the doubly charged scalar to the right-handed leptons.Meanwhile, a one-loop induced neutrinoless double beta decay can arrive at a testable level even if the electron neutrino has an extremely small Majorana mass.We also study other experimental constraints and implications including some rare processes and Higgs phenomenology.